Search results for "Estrogenic compound"
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Direct antioxidant and protective effect of estradiol on isolated mitochondria
2009
AbstractEstrogens have antioxidant properties which are due to their ability to bind to estrogen receptors and to up-regulate the expression of antioxidant enzymes via intracellular signalling pathways. Mitochondria are key organelles in the development of age-associated cellular damage. Recently, estrogen receptors were identified in mitochondria. The aim of this paper was to test whether estradiol directly affects mitochondria by preventing oxidative stress and protecting frail mitochondria. Incubation with estradiol at normal intracellular concentrations prevents the formation of reactive oxygen species by mitochondria in a saturable manner. Moreover, estradiol protects mitochondrial int…
Women Live Longer than Men: Understanding Molecular Mechanisms Offers Opportunities to Intervene by Using Estrogenic Compounds
2010
Abstract Women live longer than men. Moreover, females live longer than males in some, but not all, experimental animals. The differences in longevity between genders are related to free radical production. Indeed, females produce less radicals only in animal species in which they live longer than males. This is because estrogens upregulate antioxidant longevity-related genes. These considerations have led us to postulate an extended concept of antioxidant in biology: an antioxidant is any nutritional, physiological, or pharmacological manipulation that increases the expression and activity of antioxidant genes or proteins. Phytoestrogens or other selective estrogen receptor modulators lowe…